Public vote counts should help a lot towards catching manipulation on the fediverse. Any action that can affect visibility (upvotes and comments) can be pulled by researchers through federation to study/catch inorganic behavior.
I'd love to see some type of Adblock like crowd sourced block lists. If the growth of other platforms is any indication there will probably be a day where it would be nice to block out a large amounts of accounts. I'd even pay for it.