I believe there's a Dierks Bently song about this too, 5-1-5-0

Infertility/miscarriage, menopause, loss of breasts or uterus to cancer, perhaps being unable to attract a partner or being 'friend zoned', trouble bonding with child maybe caused by ppd, loss of hair, accidently mistaken as being a man, failure at traditionally seen as women's work such as cooking or keeping a clean house

And I'm not sure effeminization is right. When I hear that, I think of a feminized male, not a defeminized female.