At least so far. The first go round had the nozzle crash into the tree support, resulting in a layer shift. The good news is that the print stayed very firmly stuck to the bed.
I've reset, lowered my extrusion multiplier a smidge, switched to a more traditional support pattern, and am going for it again. Wish me luck!
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Yes, I've done skirts. At a certain print size/aspect ratio it doesn't really matter though - the parts are going to want to warp without a warm enclosure. If you have great first layer adhesion it will just take your build plate with it. You'll find a picture of that happening on this printer if you look through my post history.
Smaller parts in x/y and round corners will help prevent warping.
I printed all the parts for my Voron using an i3 clone under a cardboard box. I doubt that "chamber" got very warm, but it was enough for success.