Basically the only road block I've seen is a lot of games using anti-cheat software just refuse to allow Linux. Some of it even has an option to allow it to run under proton and the devs don't enable that option so it's blocked. It's basically them saying they don't trust the Linux community not to cheat.

Then you get into the root-kit anti-cheat stuff like valorant uses which wants to load before the os and then control and monitor everything the os does and what hardware is connected... I've stayed away from the invasive as fuck anti-cheat games for years even before my move to Linux, so nothing lost there.