Onedrive /google drive for immediate stuff. Other stuff (too big for cloud services) from local to Synology, or simply served from Synology. Cloudsync from OneDrive/Google drive to Synology. (Periodic verification that things are sync'd this is very important!). Snapshots on Synology for local 'oops' recovery. Synology hyperbackup to Wasabi for catastrophic recovery. (used to use Glacier for this but it was a bit unwieldy for the amount of money saved - I don't have that much data)

I'm aware that the loopback from onedrive/Google drive to synology doubles network traffic in the background but, again, I don't have that much data and a consistent approach makes things easier/safer in the long run. And with more than one computer sharing a cloud drive link, the redundancy/complexity is further diminished. (let the cloud drive experts deal solving race conditions and synchronization/concurrency fun).

This works because every computer I have can plug into the process. Everything ends up on Synology (direct or via onedrive/Google drive) and everything ends up off site at Wasabi.

I very rarely need to touch the Wasabi stuff (unless to test, or because of boneheaded mistakes I make (not often) while configuring things.

It's a good model (for me), adapts well to almost every situation and let's me control my data.